Jürgen Burhenne Selected Research

Cytochrome P-450 CYP3A Inhibitors

1/2021	Pharmacoenhancement of Low Crizotinib Plasma Concentrations in Patients with Anaplastic Lymphoma Kinase-Positive Non-Small Cell Lung Cancer using the CYP3A Inhibitor Cobicistat.
8/2006	Potent cytochrome P450 2C19 genotype-related interaction between voriconazole and the cytochrome P450 3A4 inhibitor ritonavir.

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Jürgen Burhenne Research Topics

Disease

13	Neoplasms (Cancer) 03/2022 - 05/2011
9	Malaria 06/2014 - 12/2004
6	Multiple Myeloma 06/2021 - 06/2014
5	Body Weight (Weight, Body) 01/2020 - 12/2004
5	Pulmonary Arterial Hypertension 09/2017 - 01/2013
4	Tuberculosis (Tuberculoses) 01/2020 - 08/2016
3	Coinfection 01/2021 - 08/2016
3	Brain Neoplasms (Brain Tumor) 08/2019 - 05/2012
3	Infections 09/2017 - 09/2006
3	Critical Illness (Critically Ill) 09/2017 - 09/2006
3	Falciparum Malaria (Plasmodium falciparum Malaria) 06/2010 - 01/2005
2	Ischemic Stroke 01/2022 - 01/2019
2	Stroke (Strokes) 01/2022 - 01/2019
2	Glioblastoma (Glioblastoma Multiforme) 12/2021 - 10/2015
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2021 - 09/2007
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2021 - 07/2020
2	Atrial Fibrillation 01/2019 - 01/2018
2	Renal Insufficiency (Renal Failure) 09/2017 - 09/2006
2	Sarcoma (Soft Tissue Sarcoma) 08/2017 - 01/2016
2	Erectile Dysfunction 01/2016 - 12/2005
2	Aspergillosis 09/2008 - 09/2006
2	Drug-Related Side Effects and Adverse Reactions 08/2006 - 03/2004
1	Breast Neoplasms (Breast Cancer) 02/2022
1	Neuroblastoma 01/2022
1	Alcoholic Liver Diseases (Alcoholic Liver Disease) 01/2022
1	Ependymoma 09/2021
1	Hepatitis D 09/2021
1	Hepatitis B 09/2021
1	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 06/2021
1	Acromegaly 02/2021
1	Pituitary ACTH Hypersecretion 02/2021
1	Acute Promyelocytic Leukemia 01/2021
1	Psychological Sexual Dysfunctions (Sexual Arousal Disorder) 07/2020

Drug/Important Bio-Agent (IBA)

16	Pharmaceutical PreparationsIBA 03/2022 - 01/2005
10	Voriconazole (Vfend)FDA LinkGeneric 09/2017 - 08/2006
8	Methylene Blue (Methylthioninium Chloride)FDA Link 06/2010 - 12/2004
6	efavirenz (Sustiva)FDA Link 01/2021 - 01/2011
6	Sildenafil Citrate (Viagra)FDA Link 01/2017 - 12/2005
5	Cytochrome P-450 CYP3AIBA 02/2022 - 03/2005
5	Rifampin (Rifampicin)FDA LinkGeneric 01/2021 - 09/2007
5	Vorinostat FDA Link 12/2019 - 08/2014
5	Phosphodiesterase 5 InhibitorsIBA 09/2017 - 01/2013
4	Proteins (Proteins, Gene)FDA Link 02/2022 - 03/2008
4	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2021 - 05/2011
4	Bortezomib (Velcade)FDA Link 01/2019 - 06/2014
4	Tadalafil (Cialis)FDA Link 01/2017 - 01/2013
4	Antimalarials (Antimalarial Agents)IBA 06/2014 - 03/2008
4	Chloroquine (Aralen)FDA LinkGeneric 10/2006 - 12/2004
3	AnticoagulantsIBA 01/2022 - 01/2018
3	EnzymesIBA 01/2020 - 03/2005
3	Endothelin Receptor AntagonistsIBA 09/2017 - 12/2015
3	ambrisentan FDA Link 01/2017 - 01/2013
3	Bosentan (Tracleer)FDA Link 01/2017 - 01/2013
3	RetinoidsIBA 10/2015 - 05/2011
3	Drug CombinationsIBA 10/2006 - 01/2005
2	Cytochrome P-450 CYP2C19IBA 02/2022 - 08/2006
2	Peptides (Polypeptides)IBA 02/2022 - 02/2021
2	SodiumIBA 09/2021 - 09/2006
2	Dexamethasone (Maxidex)FDA LinkGeneric 06/2021 - 10/2014
2	Cytochrome P-450 CYP3A InhibitorsIBA 01/2021 - 08/2006
2	ceritinibIBA 03/2020 - 08/2019
2	Midazolam (Versed)FDA LinkGeneric 01/2020 - 01/2014
2	Histone Deacetylase InhibitorsIBA 12/2019 - 08/2014
2	Melphalan (Alkeran)FDA LinkGeneric 01/2019 - 10/2014
2	Cytochrome P-450 CYP2B6 (CYP2B6)IBA 11/2018 - 01/2017
2	Histone Deacetylases (Histone Deacetylase)IBA 08/2017 - 08/2014
2	CholesterolIBA 08/2016 - 03/2013
2	Vitamin A (Retinol)FDA LinkGeneric 10/2015 - 05/2012
2	Proteasome InhibitorsIBA 02/2015 - 06/2014
2	LipidsIBA 03/2013 - 05/2012
2	betadex (beta-cyclodextrin)IBA 07/2010 - 09/2006
2	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 12/2005 - 03/2005
1	Large Neutral Amino Acid-Transporter 1IBA 03/2022
1	Amino Acid Transport Systems (Amino Acid Transporter)IBA 03/2022
1	AnionsIBA 02/2022
1	Ketoconazole (Nizoral)FDA LinkGeneric 02/2022
1	Cytochrome P-450 CYP2D6 (CYP2D6)IBA 02/2022
1	Cystine (L-Cystine)IBA 01/2022
1	Cysteine (L-Cysteine)FDA Link 01/2022
1	Chlormethiazole (Clomethiazole)IBA 01/2022
1	Transcription Factors (Transcription Factor)IBA 01/2022
1	Cytochrome P-450 CYP2E1 (CYP2E1)IBA 01/2022
1	Temozolomide (Temodar)FDA LinkGeneric 12/2021
1	Dactinomycin (Actinomycin)FDA LinkGeneric 09/2021
1	SymportersIBA 09/2021
1	Bile Acids and Salts (Bile Acids)IBA 09/2021
1	bulevirtideIBA 09/2021
1	selinexorIBA 06/2021
1	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 02/2021
1	pasireotideIBA 02/2021
1	CobicistatIBA 01/2021
1	Anaplastic Lymphoma KinaseIBA 01/2021
1	CrizotinibIBA 01/2021
1	bremelanotideIBA 07/2020
1	osimertinibIBA 07/2020

Therapy/Procedure

21	Therapeutics 01/2021 - 03/2004
2	Highly Active Antiretroviral Therapy (HAART) 01/2020 - 08/2016
2	Drug Therapy (Chemotherapy) 01/2016 - 10/2014
2	Renal Replacement Therapy (Therapies, Renal Replacement) 06/2010 - 09/2006
1	Radiotherapy 12/2021